What is Dihydroberberine?

Berberine VS Dihydroberberine?

Dihydro berberine is a derivative of berberine and has a higher bioavailability and stronger pharmacological activity.
（1）Higher bioavailability
Hydroxypinusine is absorbed more quickly in the intestine, with a bioavailability more than 4.8 times that of berberine. Studies have shown that its absorption rate is 11.9 times that of berberine, and it is not easily affected by intestinal transport proteins, enabling it to be more efficiently converted into an active form to exert its effect.
（2）The health benefits are more significant.
Better hypoglycemic effect: In the high-fat diet rat model, the hypoglycemic effect of 100mg/kg dihydro berberine is equivalent to that of 560mg/kg berberine, and it can enhance insulin sensitivity.
Prominent fat reduction effect: It can effectively reduce fat accumulation, improve fat metabolism, and has a significant improvement effect on metabolic disorders related to obesity.
Anti-atherosclerosis: It can significantly reduce the area of atherosclerotic plaques (up to 44.4%), which is better than berberine (15.5%).
Anti-colitis: Its therapeutic effect on ulcerative colitis is better than that of berberine, and it can promote intestinal mucosa repair and reduce inflammatory responses.
Liver protection effect: By up-regulating the level of liver microRNA (mir-122), it improves fatty liver and liver damage caused by iron overload, regulates lipid metabolism and oxidative stress.

What does Dihydroberberine do?

Regulate blood sugar and fat metabolism: It can effectively lower blood sugar levels, improve insulin sensitivity, reduce fat accumulation, and potentially be helpful for obesity and diabetes management.
Protect the liver: By upregulating the expression of the mir-122 gene in the liver, it inhibits fat synthesis and oxidative damage, and improves metabolic liver diseases such as non-alcoholic fatty liver disease.
Anti-inflammatory and antioxidant: Reduces inflammatory responses, reduces oxidative stress damage, and has certain protective effects on intestinal inflammation, cardiovascular diseases, etc.

Specifications

BN Q & A